2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

Base Information

Chemical Name:2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester
CAS No.:303155-26-2
Molecular Formula:C₁₄H₂₀N₂O₄
Molecular Weight:280.324
Hs Code.:

Synonyms:2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

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Chemical Property of 2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

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Technology Process of 2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

There total 6 articles about 2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 303155-23-9
4-(3-methyl-2-oxo-cyclohexyl)-3-oxo-pentanoic acid ethyl ester

: 303155-26-2
2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

Guidance literature:: With triethylamine; Methanesulfonyl azide; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4020(00)00569-X

Reference yield:

: 5049-51-4
6-methyl-1-pyrrolidino-1-cyclohexene

: 303155-26-2
2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.15 g / benzene / 15 h / Heating

2.1: 90 percent / aq. KOH / 8 h / 20 °C

3.1: (COCl)2 / diethyl ether / 2 h / 25 °C

4.1: iPrMgBr / CH₂Cl₂; tetrahydrofuran / 40 - 50 °C

4.2: 810 mg / CH₂Cl₂; tetrahydrofuran

5.1: 96 percent / MsN₃; Et₃N / CH₂Cl₂ / 20 °C

With potassium hydroxide; oxalyl dichloride; isopropylmagnesium bromide; triethylamine; Methanesulfonyl azide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 1.1: Alkylation / 2.1: Hydrolysis / 3.1: Substitution / 4.1: Metallation / 4.2: Condensation / 5.1: diazo transfer;
DOI:10.1016/S0040-4020(00)00569-X

Reference yield:

: 99181-55-2
2-(3-methyl-2-oxocyclohexyl)propionic acid

: 303155-26-2
2-diazo-4-methyl-4-(3-methyl-2-oxocyclohexyl)-3-oxobutanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2 / diethyl ether / 2 h / 25 °C

2.1: iPrMgBr / CH₂Cl₂; tetrahydrofuran / 40 - 50 °C

2.2: 810 mg / CH₂Cl₂; tetrahydrofuran

3.1: 96 percent / MsN₃; Et₃N / CH₂Cl₂ / 20 °C

With oxalyl dichloride; isopropylmagnesium bromide; triethylamine; Methanesulfonyl azide; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Substitution / 2.1: Metallation / 2.2: Condensation / 3.1: diazo transfer;
DOI:10.1016/S0040-4020(00)00569-X