5049-51-4

Usage

Uses

Used in Pharmaceutical and Bioactive Molecule Synthesis:
1-(6-Methyl-1-cyclohexenyl)pyrrolidine is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs and bioactive molecules. Its unique structure allows for the creation of a diverse range of compounds with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(6-Methyl-1-cyclohexenyl)pyrrolidine serves as a valuable research tool. Its structural properties make it an ideal candidate for the development of novel compounds with potential applications in treating various diseases and medical conditions.
Used in Material Science and Industrial Processes:
1-(6-Methyl-1-cyclohexenyl)pyrrolidine may also have applications in material science and the development of new industrial processes. Its unique chemical properties could contribute to the creation of innovative materials and techniques that can be utilized across various industries.
Used in Biological Activity Studies:
Due to its potential biological activity, 1-(6-Methyl-1-cyclohexenyl)pyrrolidine is of interest in the study of its pharmacological properties and possible medical uses. Researchers may explore its interactions with biological systems to identify new therapeutic opportunities and applications in medicine.

Upstream product

• 123-75-1 pyrrolidine 
• 583-60-8 2-Methylcyclohexanone 

Downstream Products

• 21197-29-5 3-(3-methyl-2-oxo-cyclohexyl)-propionitrile 
• 93947-42-3 7-methyl-3-phenyl-7a-pyrrolidin-1-yl-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole 
• 20007-17-4 2-Methyl-2-(β-benzoyl-aethyl)-cyclohexanon 
• 73336-26-2 2-(2-Bromallyl)-6-methylcyclohexanon 
• 41832-34-2 3-methyl-2-oxo-cyclohexanecarbonitrile 
• 91807-72-6 2-<2.4-Dinitro-phenyl>-6-methyl-cyclohexanon 
• 29647-91-4 2-tropyl-2-methylcyclohexanone 
• 58000-16-1 cis-2-(4-methoxybenzyl)-6-methylcyclohexanone 
• 58000-16-1 trans-2-(4-methoxybenzyl)-6-methylcyclohexanone 
• 158096-71-0 2-(4-hydroxybenzyl)-6-methylcyclohexan-1-one 
• 303155-22-8 ethyl 2-(3-methyl-2-oxocyclohexyl)propionate 
• 41378-30-7 1-(2-methylphenyl)pyrrolidine 
• 72009-05-3 2-Methyl-6-(2-oxopropyl)cyclohexanone 
• 16022-25-6 3-(3-methyl-2-oxocyclohexyl)propanoic acid 

Relevant academic research and scientific papers

Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis

The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.

Enamines as Surrogates of Alkene Carbanions for the Reductive Alkenylation of Secondary Amides: An Approach to Allylamines

A new strategy to construct allylamines through reductive alkenylation of secondary amides with enamines is reported. The method features the use of trifluoromethanesulfonic anhydride as an activation reagent of amides, and enamines as unconventional alkenylation reagents. In this manner, enamines serve as surrogates of alkene carbanions instead of the classical enolates equivalents. A possible mechanism involving a Hoffmann-like elimination of the amine-borane complex intermediate is proposed.

High-performance hypoiodite/hydrogen peroxide catalytic system for the oxylactonization of aliphatic γ-oxocarboxylic acids

Highly efficient hypoiodite-catalyzed oxylactonization of aliphatic γ-oxocarboxylic acids to the corresponding γ-acyl-γ-butyrolactones was developed. Highly dilute reaction conditions and slow addition of the oxidant are both highly effective for promotin

New, general, and practical enamine cyclopropanation using dichloromethane

Dichloromethane serves as a novel electrophilic carbene equivalent which adds to an enamine double bond. The presence of other alkene moieties in the enamine partner is well tolerated. Even enamines derived from sterically hindered ketones react readily with dichloromethane promoted by TiCl 4-Mg.

Facile synthesis of oxatricyclic systems with various ring sizes and substituents

A series of α-diazo carbonyl compounds having cyclopentanone, cyclohexanone and substituted cyclohexanone units with different tether lengths have been synthesized using diazomethane solution or methanesulphonyl azide. The above synthesized α-diazo carbon

Synthesis of juvenile hormone bioanalogs derived from 2-(4-hydroxybenzyl)-6-methylcyclohexanone

A new simple approach to isomeric 2-(4-alkoxybenzyl)-6-methylcyclohexanones and the corresponding alcohols and a subsequent synthesis of compounds imitating the action of the insect juvenile hormones is described. Biological activity of the isomeric juven

Synthesis and structure-activity relationships of juvenoids derived from 2-(4-hydroxybenzyl)cycloalkan-1-ones

Juvenoids 16-30, 32, 36, 38-41, 44-46, and 49-56 containing carbamate, carbonate, and urea moieties in the molecule were synthesized and subjected to a biological screening. Carbamate juvenoids 1-4 were used as reference compounds for a detailed structure-activity study of their analogues. A clear relationship between the nature of the side chain functional group and the biological activity was found. Surprisingly, not only the juvenoids 1,4 but also 38-41, the compounds with a reversed carbamate N,O-substitution pattern, showed very promising biological activity. In contrast, the carbonate and urea derivatives displayed a remarkably low activity. The relationship between the size and substitution at atoms C(2) and C(3) of the saturated ring and the biological activity is very complex and is still not completely understood.

178. Stereoselectivity of the Radical Reductive Alkylation of Enamines: Importance of the Allylic 1,3-Strain Model

Radical addition to enamines using Bu3SnH as reducing agent are reported (Schemes 2 and 4).The diastereoselectivity of these reactions was examined in different systems (Tables 1 and 2).Enamines derived from cyclic ketones such as cyclohexanone were alkyl

REGIOSPECIFIC SYNTHESIS OF α-ARYLSULFONOXY KETONES FROM KETONE DERIVATIVES

Isomeric enol ester, enamine, and silyl enol ether derivatives of unsymmetrical ketones are converted regiospecifically to α-arylsulfonoxy ketones with arylsulfonyl peroxides.