Technology Process of ethyl trans-4-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]cyclohexanecarboxylate
There total 4 articles about ethyl trans-4-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]cyclohexanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / 2 h / 70 °C
2.1: triethylamine / dichloromethane / 25 °C
3.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 80 °C
4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 20 °C
4.2: 2 h / 20 °C
With
18-crown-6 ether; sulfuric acid; isopropylmagnesium chloride; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
ethyl trans-4-(4-iodo-3-methyl-1H-pyrazol-1-yl)cyclohexanecarboxylate;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 25 °C
2.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 80 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 20 °C
3.2: 2 h / 20 °C
With
18-crown-6 ether; isopropylmagnesium chloride; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
