cis-Ethyl 4-hydroxycyclohexanecarboxylate

Base Information

• Chemical Name: cis-Ethyl 4-hydroxycyclohexanecarboxylate
• CAS No.: 75877-66-6
• Molecular Formula: C9H16O3
• Molecular Weight: 172.224
• Mol file: 75877-66-6.mol

Synonyms:Cyclohexanecarboxylic acid,4-hydroxy-,ethyl ester;1-ethoxycarbonyl-4-hydroxycyclohexane;Ethyl4-hydroxycyclohexanecarboxylate;4-hydroxycyclohexanecarboxylic acid ethyl ester;Ethyl 4-hydroxycyclohexanecarboxylate,mixture of cis and trans;Ethyl 4-hydroxycyclohexanecarboxylate,cis + trans;4-Hydroxycyclohexane-1-carboxylic acid ethyl ester;cis/trans-ethyl 4-hydroxycyclohexanecarboxylate;4-Hydroxycyclohexanecarboxylate;4-hydroxycyclohexyl carboxylic acid ethyl ester;

Chemical Property of cis-Ethyl 4-hydroxycyclohexanecarboxylate

Chemical Property:

• Boiling Point: 251.4±33.0 °C(Predicted)
• PKA: 14.98±0.40(Predicted)
• PSA: 46.53000
• Density: 1.093±0.06 g/cm3(Predicted)
• LogP: 1.10060

Purity/Quality:

97% ^*data from raw suppliers

Cis-4-Hydroxy-cyclohexanecarboxylicacidethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-Ethyl 4-hydroxycyclohexanecarboxylate

There total 18 articles about cis-Ethyl 4-hydroxycyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 4-hydroxycyclohexanecarboxylic acid (3685-22-1,3685-26-5,17419-81-7) → 4-hydroxycyclohexyl carboxylic acid ethyl ester (3618-04-0,75877-66-6,17159-80-7)

Guidance literature:

ethanol; 4-hydroxycyclohexanecarboxylic acid; With sulfuric acid; for 16h; Heating / reflux;

With water; sodium carbonate; In ethanol;

Reference yield: 100.0%

Ethyl 4-hydroxybenzoate (120-47-8) → 4-hydroxycyclohexyl carboxylic acid ethyl ester (3618-04-0,75877-66-6,17159-80-7)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In ethanol; at 20 ℃; for 20h; under 3800 Torr;

DOI:10.1248/bpb.18.407

Reference yield: 99.0%

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) → 4-hydroxycyclohexyl carboxylic acid ethyl ester (3618-04-0,75877-66-6,17159-80-7)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00908

upstream raw materials:

Ethyl 4-hydroxybenzoate

ethyl 4-oxocyclohexane-1-carboxylate

ethanol

4-hydroxycyclohexanecarboxylic acid

Downstream raw materials:

4-chloro-1-cyclohexanecarboxylic acid chloride

1-Phenylsulfon-2-oxo-2-(4-hydroxy-cyclohexyl)ethan

ethyl 4-oxocyclohexane-1-carboxylate

4-hydroxycyclohexane-1-carboxamide