Technology Process of 3-nitro-4-hydroxy-phenylethyl acetate
There total 1 articles about 3-nitro-4-hydroxy-phenylethyl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 98 percent / NaHSO4; silica / hexane / Heating
2: 83 percent / aq. HNO3; AcOH / 1 h / 15 °C
With
sodium hydrogen sulfate; nitric acid; silica gel; acetic acid;
In
hexane;
DOI:10.1021/jo0526237
- Guidance literature:
-
With
ethanol; palladium 10% on activated carbon;
at 25 ℃;
for 2h;
under 2250.23 Torr;
Pressure;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridine / CH2Cl2 / 0 - 20 °C
2.1: 400 mg / Pd(dppf)Cl2; K2CO3 / tetrahydrofuran; H2O / 89 °C
3.1: 98 percent / NaOMe; MeOH / 4 h / 20 °C
4.1: Et3N / CH2Cl2 / 1 h / 0 °C
5.1: 370 mg / LiI; n-Bu4NI / tetrahydrofuran / 1 h / 20 °C
6.1: LiOH*2H2O / dimethylformamide / Heating
6.2: 60 percent / dimethylformamide / 20 h / 20 °C
7.1: 95 percent / H2 / Pd/C / ethanol / 6 h / 36 °C
8.1: NaNO2; aq. HCl / 0.25 h / 0 °C
8.2: 90 percent / NaN3; aq. HCl / 0.5 h / 0 °C
With
pyridine; hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; hydrogen; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; lithium iodide; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
2.1: Suzuki coupling;
DOI:10.1021/jo0526237
