2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

Base Information

Chemical Name:2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol
CAS No.:881914-35-8
Molecular Formula:C₁₉H₃₂N₄O₂
Molecular Weight:348.489
Hs Code.:

Synonyms:

Suppliers and Price of 2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

There total 10 articles about 2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 881914-44-9
5-(3-amino-4-octylphenethyl)-2,2-dimethyl-1,3-dioxan-5-amine

: 881914-35-8
2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

Guidance literature:: 5-(3-amino-4-octylphenethyl)-2,2-dimethyl-1,3-dioxan-5-amine; With hydrogenchloride; sodium nitrite; at 0 ℃; for 0.25h;

With hydrogenchloride; sodium azide; at 0 ℃; for 0.5h;
DOI:10.1021/jo0526237

Reference yield:

: 118172-65-9
3-nitro-4-hydroxy-phenylethyl acetate

: 881914-35-8
2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / CH₂Cl₂ / 0 - 20 °C

2.1: 400 mg / Pd(dppf)Cl₂; K₂CO₃ / tetrahydrofuran; H₂O / 89 °C

3.1: 98 percent / NaOMe; MeOH / 4 h / 20 °C

4.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5.1: 370 mg / LiI; n-Bu₄NI / tetrahydrofuran / 1 h / 20 °C

6.1: LiOH*2H₂O / dimethylformamide / Heating

6.2: 60 percent / dimethylformamide / 20 h / 20 °C

7.1: 95 percent / H₂ / Pd/C / ethanol / 6 h / 36 °C

8.1: NaNO₂; aq. HCl / 0.25 h / 0 °C

8.2: 90 percent / NaN₃; aq. HCl / 0.5 h / 0 °C

With pyridine; hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; hydrogen; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; lithium iodide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Suzuki coupling;
DOI:10.1021/jo0526237

Reference yield:

: 881914-40-5
4-(2-iodoethyl)-2-nitro-1-((E)-oct-1-enyl)benzene

: 881914-35-8
2-(3-azido-4-octylphenethyl)-2-aminopropane-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiOH*2H₂O / dimethylformamide / Heating

1.2: 60 percent / dimethylformamide / 20 h / 20 °C

2.1: 95 percent / H₂ / Pd/C / ethanol / 6 h / 36 °C

3.1: NaNO₂; aq. HCl / 0.25 h / 0 °C

3.2: 90 percent / NaN₃; aq. HCl / 0.5 h / 0 °C

With hydrogenchloride; lithium hydroxide; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo0526237