R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt

Base Information

• Chemical Name: R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt
• CAS No.: 1429299-06-8
• Molecular Formula: C₁₀H₁₅NO*C₂₂H₁₉BrO₃
• Molecular Weight: 576.53
• Mol file: 1429299-06-8.mol

Synonyms:R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt

Chemical Property of R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt

There total 3 articles about R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1185739-54-1) + (1S,2R)-(+)-ephedrine (321-98-2,7009-81-6,90-83-5,6912-63-6) → R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt (1429299-06-8)

Guidance literature:

In ethanol; at 0 - 75 ℃; for 5.83333h;

Reference yield:

benzyl chloride (100-44-7) → R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt (1429299-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / 60 - 65 °C

2: sodium hydroxide / water / 45 - 50 °C

3: ethanol / 5.83 h / 0 - 75 °C

With potassium carbonate; sodium hydroxide; In ethanol; water;

Reference yield:

methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate (156755-24-7) → R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt (1429299-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 45 - 50 °C

2: ethanol / 5.83 h / 0 - 75 °C

With sodium hydroxide; In ethanol; water;

upstream raw materials:

benzyl chloride

methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate

(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid

(1S,2R)-(+)-ephedrine

Downstream raw materials:

R-(-)3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid

(3R)-3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoyl chloride

R-(-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionamide

R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine