Benzenepropanoic acid, 5-bromo-.beta.-phenyl-2-(phenylmethoxy)-, methyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 5-bromo-.beta.-phenyl-2-(phenylmethoxy)-, methyl ester
• CAS No.: 156755-24-7
• Molecular Formula: C23H21BrO3
• Molecular Weight: 425.322
• Mol file: 156755-24-7.mol

Synonyms:ethyl 3-(3-ethoxy-3-oxopropyl)-2-oxocyclopentanecarboxylate;3-(3-Aethoxycarbonyl-2-oxo-cyclopentyl)-propionsaeure-aethylester;2-Oxo-3-(2-carboxy-aethyl)-cyclopentan-carbonsaeure-(1);methyl (+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionate;3-(3-ethoxycarbonyl-2-oxo-cyclopentyl)-propionic acid ethyl ester;(+-)-3-(2-Aethoxycarbonyl-aethyl)-2-oxo-cyclopentancarbonsaeure-aethylester;1-Aethoxycarbonyl-3-(2-aethoxycarbonyl-aethyl)-cyclopentanon-(2);methyl 3-(2-(benzyloxy)-5-bromophenyI)-3-phenylpropanoate;3-(2-Oxo-3-carboxy-cyclopentyl)-propionsaeure;(+-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid methyl ester;methyl 3-(2-(benzyloxy)-5-bromophenyl)-3-phenylpropanoate;3-ethoxycarbonylethyl-2-oxo-cyclopentane-carboxylic acid ethylester;

Chemical Property of Benzenepropanoic acid, 5-bromo-.beta.-phenyl-2-(phenylmethoxy)-, methyl ester

Chemical Property:

• Boiling Point: 527.0±50.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.314±0.06 g/cm3(Predicted)
• LogP: 5.72310

Purity/Quality:

97% ^*data from raw suppliers

Benzenepropanoicacid,5-bromo-b-phenyl-2-(phenylmethoxy)-,methylester,(±)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, 5-bromo-.beta.-phenyl-2-(phenylmethoxy)-, methyl ester

There total 4 articles about Benzenepropanoic acid, 5-bromo-.beta.-phenyl-2-(phenylmethoxy)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

methanol (67-56-1) + 6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one (156755-23-6) + benzyl chloride (100-44-7) → methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate (156755-24-7)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 6h; Reflux;

Reference yield:

Cinnamic acid (621-82-9) → methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate (156755-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 4 h / 25 - 125 °C

2: potassium carbonate; sodium iodide / acetone / 2 h / 25 - 60 °C

With sulfuric acid; potassium carbonate; sodium iodide; In acetone;

Reference yield:

(E)-3-phenylacrylic acid (140-10-3) → methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate (156755-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 120 - 125 °C

2: potassium carbonate; sodium iodide / acetone / Reflux

With sulfuric acid; potassium carbonate; sodium iodide; In acetone;

upstream raw materials:

methanol

6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one

benzyl chloride

(E)-3-phenylacrylic acid

Downstream raw materials:

methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate

R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

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