(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

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Chemical Name:(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
CAS No.:188302-86-5
Molecular Formula:C₂₁H₂₈N₄O₃
Molecular Weight:384.478
Hs Code.:

Synonyms:(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

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Chemical Property of (S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

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Technology Process of (S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

There total 6 articles about (S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 188302-85-4
[(S)-1-Cyclohexyl-2,4-dioxo-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid (S)-1-phenyl-ethyl ester

: 188302-86-5
(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1016/S0960-894X(96)00613-0

Reference yield:

: 74628-31-2
N-1-cyclohexylbenzene-1,2-diamine

: 188302-86-5
(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / K₂CO₃ / dimethylformamide

2: 93 percent / tetrahydrofuran

3: 81 percent / Zn, glacial AcOH

5: 89 percent / H₂ / Pd/C

With hydrogen; potassium carbonate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00613-0

Reference yield:

: 90892-09-4
bromoacetopyrrolidine

: 188302-86-5
(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / K₂CO₃ / dimethylformamide

2: 93 percent / tetrahydrofuran

3: 81 percent / Zn, glacial AcOH

5: 89 percent / H₂ / Pd/C

With hydrogen; potassium carbonate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00613-0