90892-09-4

Basic information

• Product Name: Pyrrolidine, 1-(bromoacetyl)- (6CI,9CI)
• Synonyms: Pyrrolidine, 1-(bromoacetyl)- (6CI,9CI);2-bromo-1-(1-pyrrolidinyl)Ethanone;1-(bromoacetyl)-Pyrrolidine;2-BROMO-1-(PYRROLIDIN-1-YL)ETHAN-1-ONE
• CAS NO: 90892-09-4
• Molecular Formula: C₆H₁₀BrNO
• Molecular Weight: 192.0537
• Product Categories: ACETYLHALIDE
• Mol File: 90892-09-4.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 120 °C/0.1 mmHg
• Appearance: /
• CAS DataBase Reference: Pyrrolidine, 1-(bromoacetyl)- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(bromoacetyl)- (6CI,9CI)(90892-09-4)
• EPA Substance Registry System: Pyrrolidine, 1-(bromoacetyl)- (6CI,9CI)(90892-09-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 90892-09-4(Hazardous Substances Data)

Usage

General Description

Pyrrolidine, 1-(bromoacetyl)- (6CI,9CI) is a chemical compound with the formula C6H10BrNO. It is a derivative of pyrrolidine, which is a cyclic amine commonly found in various naturally occurring substances. The addition of the bromoacetyl group to the pyrrolidine molecule gives it potential applications in organic synthesis and pharmaceutical research. It is important to note that this compound may have specific hazards, and proper safety measures should be followed when handling and working with it.

Upstream product

• 123-75-1 pyrrolidine 
• 22118-09-8 2-bromoacetyl chloride 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 425618-70-8 2-(phenylthio)-N,N-(tetramethylene)acetamide 
• 1191099-55-4 pyrrolidin-1-yl-2-(2-vinylphenoxy)-ethanone 
• 1239486-29-3 1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-3-(phenylmethyl)-1H-imidazolium bromide 
• 807372-38-9 (E)-3-(3,5-dimethoxyphenyl)-1-(pyrrolidin-1-yl)prop-2-en-1-one 
• 1703-35-1 (E)-1-(pyrrolidine-1-yl)-3-(3,4,5-trimethoxyphenyl)-prop-2-en-1-one 
• 28044-44-2 cinepazide maleate 

Relevant articles and documents

Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues

Violacin A, a chromanone derivative, isolated from a fermentation broth of Streptomyces violaceoruber, has excellent anti-inflammatory potential. Herein, a biogenetically modeled approach to synthesize violacin A and twenty-five analogues was described, which involved the preparation of aromatic polyketide precursor through Claisen condensation and its spontaneous cyclization. The inhibitory effect on nitric oxide (NO) production of all synthetic molecules was evaluated by lipopolysaccharide (LPS)-induced Raw264.7 cells. The results revealed that introduction of aliphatic amine moieties on C-7 obviously improved the anti-inflammation effect of violacin A, and also the aromatic ether instead of ketone group at side chain was favorable to increase the activity. Among them, analogue 7a and 16d were screened as the most effective anti-inflammatory candidates. Molecular mechanism research revealed that 7a and 16d acquired anti-inflammatory ability due to the inhibition of NF-κB signaling pathway.

Imidazo ring PAR4 antagonist and medical applications thereof

The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.

First mechanosynthesis of piperlotines A, C, and derivatives through solvent-free Horner–Wadsworth–Emmons reaction

Piperlotines are natural products characterized by an α,β-unsaturated amide moiety. These compounds found wide applications in Medicinal Chemistry like antibacterials, cytotoxic agents, anticoagulants, among others. To date, diverse methods of synthesis have been reported for piperlotines, but involving the use of catalysts, hazard reagents, anhydrous media or coupling reagents. Thus, in this work, we developed a greener method of synthesis of piperlotines A, C, and derivatives, through mechanochemical activation under solvent-free conditions. The reaction of a β-amidophosphonate, K2CO3, and an aromatic aldehyde afforded target compounds in moderate to good yields (46–77%), in an open atmosphere by grinding. It is worth to mention that this mechanochemical process was under thermodynamic control because just E isomer was isolated for every reaction. Moreover, synthesized piperlotines have been predicted by means of chemoinformatic analysis as potential therapeutic agents for the treatment of arthritis or cancer.