2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester
CAS No.:250226-86-9
Molecular Formula:C₂₇H₃₆O₇
Molecular Weight:472.579
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

Suppliers and Price of 2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

There total 8 articles about 2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81972-20-5
2-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyl)ethanol

: 250226-86-9
2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

2: hydrogen / Pd(OH)2/C / ethyl acetate; methanol / 20 °C

3: CSA / dimethylformamide; CH₂Cl₂ / 20 °C

4: NaHMDS; Bu₄NI / dimethylformamide / 0 °C

5: CSA; MeOH / CH₂Cl₂ / 20 °C

With methanol; dmap; camphor-10-sulfonic acid; hydrogen; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; triethylamine; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol990885n

Reference yield:

: 82614-10-6
ethyl 2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)acetate

: 250226-86-9
2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: 100 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

3: hydrogen / Pd(OH)2/C / ethyl acetate; methanol / 20 °C

4: CSA / dimethylformamide; CH₂Cl₂ / 20 °C

5: NaHMDS; Bu₄NI / dimethylformamide / 0 °C

6: CSA; MeOH / CH₂Cl₂ / 20 °C

With methanol; dmap; camphor-10-sulfonic acid; hydrogen; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; triethylamine; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol990885n

Reference yield:

: 250226-85-8
2,2-Dimethyl-propionic acid 2-((2S,3S,4R,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

: 250226-86-9
2,2-Dimethyl-propionic acid 2-((2S,3S,4S,5R,6R)-3,4-bis-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / Pd(OH)2/C / ethyl acetate; methanol / 20 °C

2: CSA / dimethylformamide; CH₂Cl₂ / 20 °C

3: NaHMDS; Bu₄NI / dimethylformamide / 0 °C

4: CSA; MeOH / CH₂Cl₂ / 20 °C

With methanol; camphor-10-sulfonic acid; hydrogen; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol990885n