5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole

Base Information

• Chemical Name: 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole
• CAS No.: 1201005-54-0
• Molecular Formula: C₁₁H₁₁FN₂
• Molecular Weight: 190.22

Synonyms:5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole

Chemical Property of 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole

Chemical Property:

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Technology Process of 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole

There total 9 articles about 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1,2-dimethyl-1H-imidazole (1739-84-0) + 1-Bromo-4-fluorobenzene (460-00-4) → 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole (1201005-54-0)

Guidance literature:

With C₄₀H₄₀Cl₃N₃Pd; oxygen; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 130 ℃; for 12h; under 760.051 Torr; regioselective reaction;

DOI:10.1021/acs.organomet.6b00391

Reference yield: 73.0%

1,2-dimethyl-1H-imidazole (1739-84-0) + 1-Chloro-4-fluorobenzene (352-33-0) → 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole (1201005-54-0)

Guidance literature:

With C₂₀H₁₈ClN₃OPd; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 130 ℃; for 10h; Sealed tube;

DOI:10.1002/ejic.202000211

Reference yield:

C21H29N6Pd(1+)*C2H3O2(1-) → 5-(4-fluorophenyl)-1,2-dimethyl-1H-imidazole (1201005-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; dichloromethane

2: benzene

3: tetrabutylammonium acetate / chloroform / 20 °C

With tetrabutylammonium acetate; In dichloromethane; chloroform; N,N-dimethyl-formamide; benzene;

DOI:10.1002/adsc.201500888

upstream raw materials:

1,2-dimethyl-1H-imidazole

1-Bromo-4-fluorobenzene

1-Chloro-4-fluorobenzene

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