(4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol

Base Information

• Chemical Name: (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol
• CAS No.: 108483-22-3
• Molecular Formula: C₁₂H₁₆ClO₄P
• Molecular Weight: 290.683
• Mol file: 108483-22-3.mol

Synonyms:(4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol

Chemical Property of (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol

There total 2 articles about (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5,5-dimethyl-1,3-dioxaphosphorinan-2-oxide (4090-60-2) + 4-chlorobenzaldehyde (104-88-1) → (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-methanol (108483-22-3)

Guidance literature:

With triethylamine; In acetone; for 2h; Reflux;

DOI:10.1021/jacs.1c02629

Reference yield:

2,2-Dimethyl-1,3-propanediol (126-30-7) → (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-methanol (108483-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus trichloride / ethanol

2: triethylamine / chloroform

With triethylamine; phosphorus trichloride; In ethanol; chloroform;

DOI:10.1021/jf301829m

Reference yield: 93.0%

(4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-methanol (108483-22-3) → (4-chlorophenyl)(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)methanone

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jacs.1c02629

upstream raw materials:

5,5-dimethyl-1,3-dioxaphosphorinan-2-oxide

4-chlorobenzaldehyde

2,2-Dimethyl-1,3-propanediol

Downstream raw materials:

2-[Chloro-(4-chloro-phenyl)-methyl]-5,5-dimethyl-[1,3,2]dioxaphosphinane 2-oxide

2-[((2,4-dichlorophenoxy)acetyl)oxy](4-chlorophenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one

1-(4-chlorophenyl)-2-methyl-4-phenylbutan-1-one