Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

Base Information

Chemical Name:Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate
CAS No.:883554-71-0
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:2926907090
DSSTox Substance ID:DTXSID601008073
Wikidata:Q83004415
Mol file:883554-71-0.mol

Synonyms:Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate;Methyl 4-[(tert-butoxycarbonyl)amino]-1-cubanecarboxylate;SCHEMBL18089261;DTXSID601008073;AMY37447;MFCD08458195;CS-W001052;E71114;METHYL 8-[(TERT-BUTOXYCARBONYL)AMINO]CUBANE-1-CARBOXYLATE;methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]cubane-1-carboxylate;Methyl 4-{[tert-butoxy(hydroxy)methylidene]amino}cubane-1-carboxylate;methyl 4-[(tert-butoxycarbonyl)amino]pentacyclo[4.2.0.0~2,5~.0~3,8~.0~4,7~]octane-1-carboxylate

Suppliers and Price of Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Methyl (2R,3R,4S,5S)-4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate 95%
1 g
$ 2976.00

SynQuest Laboratories
Methyl (2R,3R,4S,5S)-4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate 95%
250 mg
$ 992.00

American Custom Chemicals Corporation
METHYL-4-(TERT-BUTYLCARBONYLAMINO)CUBANECARBOXYLATE 95.00%
5MG
$ 502.87

Total 10 raw suppliers

Chemical Property of Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

Chemical Property:

Vapor Pressure:1.28E-05mmHg at 25°C
Refractive Index:1.597
Boiling Point:368.3°C at 760 mmHg
Flash Point:176.6°C
PSA：64.63000
Density:1.37g/cm³
LogP:1.56540
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:277.13140809
Heavy Atom Count:20
Complexity:515

Purity/Quality:

97% ^*data from raw suppliers

Methyl (2R,3R,4S,5S)-4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC12C3C4C1C5C2C3C45C(=O)OC

Technology Process of Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

There total 1 articles about Methyl 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 24539-28-4
4-(methoxycarbonyl)-1-cubanecarboxylic acid

: 75-65-0
tert-butyl alcohol

: 883554-71-0
methyl (1r,2R,3r,4s,5S,6s,7R,8S)-4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 25 ℃; for 13h; Inert atmosphere; Reflux;
DOI:10.1021/jacs.5b12557

Reference yield: 84.0%

: 883554-71-0
methyl (1r,2R,3r,4s,5S,6s,7R,8S)-4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

: 4-((tert-butoxycarbonyl)amino)cubane-1-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/chem.201904479

Reference yield:

: 883554-71-0
methyl (1r,2R,3r,4s,5S,6s,7R,8S)-4-((tert-butoxycarbonyl)amino)cubane-1-carboxylate

: methyl (2S,4R)-4-(2-((1R,3R)-3-((2S,3S)-2-(4-acetamidocubane-1-carboxamido)-N,3-dimethylpentanamido)-1-acetoxy-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol; tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere; Cooling with ice

3: dichloromethane / 12 h / Inert atmosphere; Cooling with ice

4: pyridine / 12 h / Inert atmosphere; Cooling with ice

With pyridine; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.5b12557