1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

Base Information

Chemical Name:1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate
CAS No.:1446818-40-1
Molecular Formula:C₂₁H₂₀F₇N₃O₂
Molecular Weight:479.398
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

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Chemical Property of 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

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Technology Process of 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

There total 4 articles about 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

: 1446819-64-2
1-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine

: 1446818-40-1
1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

Guidance literature:: bis(trichloromethyl) carbonate; 1,1,1,3',3',3'-hexafluoro-propanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

1-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 1260809-13-9
tert-butyl 4-[(4-bromo-2-fluorophenyl)methyl]piperazine-1-carboxylate

: 1446818-40-1
1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 75 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 75 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4.2: 3 h / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1446819-62-0
tert-butyl 4-[[2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine-1-carboxylate

: 1446818-40-1
1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-fluoro-4-(6-methylpyridin-2-yl)phenyl]methyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 75 °C

2.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;