N-<carbonyl>sarcosine tert-butyl ester

Base Information

• Chemical Name: N-<carbonyl>sarcosine tert-butyl ester
• CAS No.: 108536-03-4
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 108536-03-4.mol

Synonyms:N-<carbonyl>sarcosine tert-butyl ester

Chemical Property of N-<carbonyl>sarcosine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<carbonyl>sarcosine tert-butyl ester

There total 2 articles about N-<carbonyl>sarcosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Pmz-Sar (108536-10-3) + tert-butyl alcohol (75-65-0) → N-<carbonyl>sarcosine tert-butyl ester (108536-03-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1021/jo00389a041

Reference yield:

4-methoxybenzyloxycarbonyl azide (25474-85-5) → N-<carbonyl>sarcosine tert-butyl ester (108536-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / 1N aq. NaOH / tetrahydrofuran / 0 - 20 °C

2: 93 percent / 4-(dimethylamino)pyridine, EDCl / CH₂Cl₂ / 22 h / 0 - 20 °C

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00389a041

upstream raw materials:

Pmz-Sar

tert-butyl alcohol

4-methoxybenzyloxycarbonyl azide