2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone

Base Information

• Chemical Name: 2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone
• CAS No.: 1100246-33-0
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 1100246-33-0.mol

Synonyms:2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone

Chemical Property of 2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone

There total 1 articles about 2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ω-(4-formylphenoxy)acetophenone (139484-40-5) + benzylamine (100-46-9) → 2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone (1100246-33-0)

Guidance literature:

In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800820

Reference yield: 73.0%

2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone (1100246-33-0) + (trifluoromethyl)trimethylsilane (81290-20-2) → 2-[4-(1-benzylamino-2,2,2-trifluoroethyl)phenoxy]-1-phenylethanone (1100246-35-2)

Guidance literature:

2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone; With potassium hydrogen difluoride; trifluoroacetic acid; In acetonitrile; at 0 ℃; for 0.0833333h; Inert atmosphere;

(trifluoromethyl)trimethylsilane; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800820

Reference yield:

2-{4-[(benzylimino)methyl]phenoxy}-1-phenylethanone (1100246-33-0) + (trifluoromethyl)trimethylsilane (81290-20-2) → C26H28F3NO2Si (1100246-37-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -20 - 4 ℃; for 18.5h; Inert atmosphere;

DOI:10.1002/ejoc.200800820

upstream raw materials:

ω-(4-formylphenoxy)acetophenone

benzylamine

Downstream raw materials:

2-[4-(1-benzylamino-2,2,2-trifluoroethyl)phenoxy]-1-phenylethanone

C₂₆H₂₈F₃NO₂Si

Refernces