2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

Base Information

Chemical Name:2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester
CAS No.:104713-41-9
Molecular Formula:C₁₃H₁₈O₆
Molecular Weight:270.282
Hs Code.:

Synonyms:2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

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Chemical Property of 2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

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Technology Process of 2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

There total 4 articles about 2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: CH₃O₂CC₆H₈BO₂C₂(CH₃)4

: 108-59-8
malonic acid dimethyl ester

: 136892-38-1
(±)-methyl 3-(1SR, 3SR)-(bis(methoxycarbonyl)methyl)-4-cyclohexenecarboxylate

: 64841-68-5,74545-66-7,79644-04-5,104713-41-9,136892-38-1
2-((1S,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; 2,6-dimethyl-1,4-benzoquinone; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; stereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0034-1380869

Reference yield:

: 87802-98-0
cis-5-[(methoxycarbonyl)oxy]-3-cyclohexene-1-carboxylic acid methyl ester

: 108-59-8
malonic acid dimethyl ester

: 136892-38-1
(±)-methyl 3-(1SR, 3SR)-(bis(methoxycarbonyl)methyl)-4-cyclohexenecarboxylate

: 104713-41-9
2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

Guidance literature:: With lithium carbonate; PS-PEG resin-supported chiral P,N-chelate Pd; In water; at 40 ℃; for 12h; Title compound not separated from byproducts.;
DOI:10.1021/ja005866j

Reference yield:

: 60729-55-7
cis-methyl 5-acetoxycyclohex-3-enecarboxylate

: 108-59-8
malonic acid dimethyl ester

: 136892-38-1
(±)-methyl 3-(1SR, 3SR)-(bis(methoxycarbonyl)methyl)-4-cyclohexenecarboxylate

: 104713-41-9
2-((1R,5R)-5-Methoxycarbonyl-cyclohex-2-enyl)-malonic acid dimethyl ester

Guidance literature:: With sodium hydride; bis(η3-allyl-μ-chloropalladium(II)); (R)-(S)-BPPF-NMeCH(CH₂OH)2; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, room temperature, 2.) THF, 0 grad C;
DOI:10.1016/S0040-4039(00)83974-X