N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Base Information

Chemical Name:N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CAS No.:1508310-54-0
Molecular Formula:C₂₆H₂₄Cl₂N₂O₃S
Molecular Weight:515.46
Hs Code.:

Synonyms:N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Technology Process of N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

There total 7 articles about N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.3%

: 1426805-26-6
pentafluorophenyl [4-(ethylsulfonyl)phenyl]acetate

: 1508310-84-6
1-(3,4-dichlorophenethyl)-1H-indol-5-amine

: 1508310-54-0
N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ml4003875

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 1508310-54-0
N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: HATU / dichloromethane / 0.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / methanol; tetrahydrofuran / 5 h / 20 °C / Cooling with ice

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 14 h / 80 °C

4.1: tin(II) chloride dihdyrate; ethanol / 28 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; tin(II) chloride dihdyrate; ethanol; boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; HATU; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ml4003875

Reference yield:

: 1508310-81-3
2-(3,4-dichlorophenyl)-1-(5-nitroindolin-1-yl)ethanone

: 1508310-54-0
N-(1-(3,4-dichlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / methanol; tetrahydrofuran / 5 h / 20 °C / Cooling with ice

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 14 h / 80 °C

3: tin(II) chloride dihdyrate; ethanol / 28 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; tin(II) chloride dihdyrate; ethanol; boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ml4003875