(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

Base Information

Chemical Name:(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione
CAS No.:1072918-25-2
Molecular Formula:C₂₀H₁₅F₃N₂O₃S
Molecular Weight:420.412
Hs Code.:

Synonyms:(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

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Chemical Property of (S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

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Technology Process of (S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

There total 6 articles about (S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072918-24-1
C₂₂H₂₀F₃NO₄S

: 1072918-25-2
(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

Guidance literature:: C₂₂H₂₀F₃NO₄S; With sodium hydrogencarbonate; In tetrahydrofuran; water; pH=~ 9;

With hydroxylamine-O-sulfonic acid; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h;

Reference yield:

: 195005-94-8
ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

: 1072918-25-2
(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / 120 °C

2.1: potassium tert-butylate / toluene / 16 h / 120 °C

3.1: Oxone / methanol; water / 24 h / 60 °C

4.1: sodium hydrogensulfide / N,N-dimethyl-formamide / 0.42 h

5.1: sodium hydrogencarbonate / tetrahydrofuran; water / pH ~ 9

5.2: 3 h / 0 - 20 °C

With Oxone; sodium hydrogensulfide; potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1072918-22-9
(S)-ethyl 1-(1-(benzyloxy)propan-2-yl)-6,7,8-trifluoro-2-(methylthio)-4-oxo-1,4-dihydroquinolme-3-carboxylate

: 1072918-25-2
(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: Oxone / methanol; water / 24 h / 60 °C

2.1: sodium hydrogensulfide / N,N-dimethyl-formamide / 0.42 h

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / pH ~ 9

3.2: 3 h / 0 - 20 °C

With Oxone; sodium hydrogensulfide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;