ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Base Information

• Chemical Name: ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate
• CAS No.: 195005-94-8
• Molecular Formula: C₁₄H₁₂F₄O₃S₂
• Molecular Weight: 368.373
• Mol file: 195005-94-8.mol

Synonyms:ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Chemical Property of ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

There total 1 articles about ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate (94695-50-8) + methyl iodide (74-88-4) → ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate (195005-94-8)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) H₂O, DMSO, 15 deg C, 20 min, 2.) DMSO, H₂O, RT, 6 h;

DOI:10.1016/S0968-0896(97)00084-9

Reference yield: 51.0%

2-aminobenzylmercaptane (95539-66-5) + ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate (195005-94-8) → ethyl 2-(2,3,4,5-tetrahydrobenzoyl)-3-(2H-1,4-dihydro-3,1-benzothiazin-2-yl)acrylate (195005-96-0)

Guidance literature:

With triethylamine; In toluene; for 24h; Heating;

DOI:10.1016/S0968-0896(97)00084-9

Reference yield:

(S)-1-(benzyloxy)-2-propylamine (83053-85-4) + ethyl 3,3-bis(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate (195005-94-8) → (S,Z)-ethyl 3-(1-(benzyloxy)propan-2-ylamino)-3-(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate (1072918-21-8)

Guidance literature:

In toluene; at 120 ℃; for 2h;

upstream raw materials:

carbon disulfide

ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

methyl iodide

Downstream raw materials:

ethyl 2-(2,3,4,5-tetrahydrobenzoyl)-3-(2H-1,4-dihydro-3,1-benzothiazin-2-yl)acrylate

(S,Z)-ethyl 3-(1-(benzyloxy)propan-2-ylamino)-3-(methylthio)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

(S)-9-(1-(benzyloxy)propan-2-yl)-6,7,8-tnfluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione

(S)-ethyl 1-(1-(benzyloxy)propan-2-yl)-6,7,8-trifluoro-2-(methylthio)-4-oxo-1,4-dihydroquinolme-3-carboxylate