Technology Process of 2-(3-Cyano-4-methoxyphenyl)nicotinic acid
There total 9 articles about 2-(3-Cyano-4-methoxyphenyl)nicotinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 2-(3-cyano-4-methoxyphenyl)-nicotinate;
With
water; sodium hydroxide;
In
ethanol;
at 70 ℃;
for 1h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 24 h / Reflux
2.1: sodium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 14 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
4.2: 3 h / 20 °C
5.1: water; sodium hydroxide / ethanol / 1 h / 70 °C
With
hydrogenchloride; water; sodium carbonate; potassium carbonate; sodium hydroxide;
palladium diacetate; toluene-4-sulfonic acid; tris-(o-tolyl)phosphine;
In
1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: formic acid; hydroxylamine hydrochloride; sodium formate / 7 h / 100 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C
2.2: 0 - 20 °C
3.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 21 h / -80 - 20 °C / Inert atmosphere
4.1: sodium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere
5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 14 h / 20 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
6.2: 3 h / 20 °C
7.1: water; sodium hydroxide / ethanol / 1 h / 70 °C
With
hydrogenchloride; n-butyllithium; formic acid; Triisopropyl borate; hydroxylamine hydrochloride; potassium tert-butylate; water; sodium formate; sodium carbonate; potassium carbonate; sodium hydroxide;
palladium diacetate; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
