2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

Base Information

Chemical Name:2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester
CAS No.:235791-23-8
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

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Chemical Property of 2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

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Technology Process of 2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

There total 6 articles about 2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 235791-22-7
2-aza-spiro[4.5]decane-4-carboxylic acid methyl ester

: 235791-23-8
2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

Guidance literature:: With pyridine; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1016/S0968-0896(99)00023-1

Reference yield:

: (+/-)-2-Aza-spiro[4.5]decane-4-carboxylic acid hydrochloride

: (OH)2/C

: 1885-14-9
phenyl chloroformate

: 247089-25-4
1-oxo-octahydro-isoindole-2-carboxylic acid tert-butyl ester

: 235791-23-8
2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

Guidance literature:: With pyridine; In methanol; n-heptane; dichloromethane;

Reference yield:

: 6802-76-2
ethyl 2-cyano-2-cyclohexylideneacetate

: 235791-23-8
2-aza-spiro<4.5>decane-2,4-dicarboxylic acid 2-benzyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / benzene / 2 h / Heating

2: aq. HCl / Heating

3: AcCl / 3 h / 95 °C

4: 97 percent / H₂ / Pd(OH)2/C / methanol / 24 h / 40 °C

5: 88 percent / pyridine / CH₂Cl₂ / 48 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; triethylamine; acetyl chloride; palladium dihydroxide; In methanol; dichloromethane; benzene;
DOI:10.1016/S0968-0896(99)00023-1