(1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester
• CAS No.: 912843-60-8
• Molecular Formula: C₁₇H₂₅N₃O₆S
• Molecular Weight: 399.468

Synonyms:(1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Chemical Property of (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester

There total 3 articles about (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R,R)-N-(4'-nitrophenylsulfonyl)-1,2-diaminocyclohexane (912843-59-5) + di-tert-butyl dicarbonate (24424-99-5) → (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester (912843-60-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1039/b608386b

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester (912843-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane; water / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

With triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1002/hc.20641

Reference yield:

(1R,2R)-1,2-diaminocyclohexane tartrate (32044-22-7,39961-95-0) → (1R,2R)-[2-(4-nitro-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester (912843-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane; water / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

With triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1002/hc.20641

upstream raw materials:

(R,R)-N-(4'-nitrophenylsulfonyl)-1,2-diaminocyclohexane

di-tert-butyl dicarbonate

4-Nitrobenzenesulfonyl chloride

(1R,2R)-1,2-diaminocyclohexane tartrate

Downstream raw materials:

(1R,2R)-[2-(4-amino-benzenesulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester

C₂₃H₃₄N₅O₅S⁽¹⁺⁾*Cl^(1-)

C₂F₃O₂^(1-)*C₂HF₃O₂*C₁₈H₂₆N₅O₃S⁽¹⁺⁾

C₂₄H₃₃N₄O₅S⁽¹⁺⁾*Cl^(1-)

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