(Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

Base Information

Chemical Name:(Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one
CAS No.:1354973-62-8
Molecular Formula:C₂₆H₃₃NO₃Si
Molecular Weight:435.638
Hs Code.:

Synonyms:(Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

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Chemical Property of (Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

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Technology Process of (Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

There total 6 articles about (Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 1354973-61-7
2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzaldehyde

: 1354973-62-8
(Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

Guidance literature:: With sodium acetate; acetic anhydride; In tetrahydrofuran; for 48h; Reflux;

Reference yield:

: 38473-89-1
3-bromo-4-(tert-butyl)benzoic acid

: 1354973-62-8
(Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 13 h / 0 - 20 °C

1.2: 22 h / 20 °C

2.1: potassium dihydrogenphosphate; trifluoroacetyl peroxide / dichloromethane / 1 h / 0 °C

2.2: 0.17 h / 20 °C

3.1: dmap; 1H-imidazole / dichloromethane / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.53 h / -78 °C

4.2: 0.5 h / -78 °C

5.1: acetic anhydride; sodium acetate / tetrahydrofuran / 48 h / Reflux

With 1H-imidazole; dmap; potassium dihydrogenphosphate; n-butyllithium; borane-THF; trifluoroacetyl peroxide; sodium acetate; acetic anhydride; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 14034-12-9
3-bromo-4-(tert-butyl)phenol

: 1354973-62-8
(Z)-4-(2-(tert-butyl)-5-((tert-butyldimethylsilyl)oxy)benzylidene)-2-phenyloxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1H-imidazole / dichloromethane / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.53 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: acetic anhydride; sodium acetate / tetrahydrofuran / 48 h / Reflux

With 1H-imidazole; dmap; n-butyllithium; sodium acetate; acetic anhydride; In tetrahydrofuran; hexane; dichloromethane;