1-(4-nitrophenyl)cyclobutanecarbonyl chloride

Base Information

• Chemical Name: 1-(4-nitrophenyl)cyclobutanecarbonyl chloride
• CAS No.: 422280-37-3
• Molecular Formula: C₁₁H₁₀ClNO₃
• Molecular Weight: 239.658
• Mol file: 422280-37-3.mol

Synonyms:1-(4-nitrophenyl)cyclobutanecarbonyl chloride

Chemical Property of 1-(4-nitrophenyl)cyclobutanecarbonyl chloride

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(4-nitrophenyl)cyclobutanecarbonyl chloride

There total 5 articles about 1-(4-nitrophenyl)cyclobutanecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-nitrophenyl)cyclobutanecarboxylic acid (202737-42-6) → 1-(4-nitrophenyl)cyclobutanecarbonyl chloride (422280-37-3)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) → 1-(4-nitrophenyl)cyclobutanecarbonyl chloride (422280-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 18 h / 65 °C

2: water; potassium hydroxide / ethanol / 24 h / Reflux

3: oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

With oxalyl dichloride; water; potassium carbonate; potassium hydroxide; In ethanol; dichloromethane; acetone;

Reference yield:

1-(4-nitrophenyl)cyclobutanecarbonitrile (1236409-69-0) → 1-(4-nitrophenyl)cyclobutanecarbonyl chloride (422280-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; potassium hydroxide / ethanol / 24 h / Reflux

2: oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

With oxalyl dichloride; water; potassium hydroxide; In ethanol; dichloromethane;

upstream raw materials:

1-(4-nitrophenyl)cyclobutanecarbonitrile

4-Nitrophenylacetonitrile

1-(4-nitrophenyl)cyclobutanecarboxylic acid