N⁶-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin

Base Information

• Chemical Name: N⁶-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin
• CAS No.: 79974-67-7
• Molecular Formula: C₄₉H₆₁N₅O₆Si₂
• Molecular Weight: 872.224
• Mol file: 79974-67-7.mol

Synonyms:N⁶-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin

Chemical Property of N⁶-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin

There total 6 articles about N⁶-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N6-Benzoyl-5'-O-(monomethoxytrityl)adenosine (69504-00-3) + tert-butyldimethylsilyl chloride (18162-48-6) → N6-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin (79974-67-7)

Guidance literature:

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide; at 60 ℃; for 6h;

Reference yield: 9.0%

N6-Benzoyl-5'-O-(monomethoxytrityl)adenosine (69504-00-3) + tert-butyldimethylsilyl chloride (18162-48-6) → N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-10-5) + N6-Benzoyl-2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-09-2) + N6-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin (79974-67-7)

Guidance literature:

With 1H-imidazole; In pyridine; for 15h; Ambient temperature;

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → N6-Benzoyl-2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin (79974-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 14 h / 50 °C

2: 9 percent / imidazol / pyridine / 15 h / Ambient temperature

With 1H-imidazole; In pyridine;

upstream raw materials:

N⁶-Benzoyl-5'-O-(monomethoxytrityl)adenosine

tert-butyldimethylsilyl chloride

N-benzoyladenosine

N⁶,N⁶,2',3',5'-pentabenzoyl-β-D-adenosine

Downstream raw materials:

N⁶-benzoyl-2',3'-bis-O-<(1,1-dimethylethyl)dimethylsilyl>adenosine