2-(ethylsulfanyl)ethyl 4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

Chemical Name:2-(ethylsulfanyl)ethyl 4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS No.:295344-04-6
Molecular Formula:C₁₆H₁₉N₃O₅S
Molecular Weight:365.41
Hs Code.:
Mol file:295344-04-6.mol

Synonyms:6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethylsulfanyl-ethyl ester

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Chemical Property of 2-(ethylsulfanyl)ethyl 4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

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Technology Process of 2-(ethylsulfanyl)ethyl 4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 4 articles about 2-(ethylsulfanyl)ethyl 4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-77-0
2-(ethylsulfanyl)ethanol

: 356566-57-9
6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid

: 295344-04-6
6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethylsulfanyl-ethyl ester

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 50 ℃; for 16h;
DOI:10.1016/j.bmcl.2006.03.102

Reference yield:

: 898798-67-9
6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester

: 295344-04-6
6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethylsulfanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaOH / acetone; H₂O / 0 - 25 °C

2: EDC; DMAP / dimethylformamide / 16 h / 50 °C

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2006.03.102

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 295344-04-6
6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethylsulfanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / BF₃*OEt₂; CuI; AcOH / tetrahydrofuran / 18 h / Heating

2: 95 percent / NaOH / acetone; H₂O / 0 - 25 °C

3: EDC; DMAP / dimethylformamide / 16 h / 50 °C

With dmap; sodium hydroxide; copper(l) iodide; boron trifluoride diethyl etherate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; 1: Biginelli condensation;
DOI:10.1016/j.bmcl.2006.03.102