1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid
• CAS No.: 356566-57-9
• Molecular Formula: C12H11 N3 O5
• Molecular Weight: 277.236
• Hs Code.: 2933599090
• Mol file: 356566-57-9.mol

Synonyms:A6225;

Chemical Property of 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid

Chemical Property:

• Vapor Pressure: 2.14E-10mmHg at 25°C
• Boiling Point: 489.5oC at 760 mmHg
• Flash Point: 249.8oC
• PSA: 127.74000
• Density: 1.439g/cm3
• LogP: 1.79930

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid

There total 6 articles about 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester (898798-67-9) → 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (356566-57-9)

Guidance literature:

With sodium hydroxide; In water; acetone; at 0 - 25 ℃;

DOI:10.1016/j.bmcl.2006.03.102

Reference yield: 80.0%

2-acetoacetic acid (541-50-4) + 4-nitrobenzaldehdye (555-16-8) + urea (57-13-6) → 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (356566-57-9)

Guidance literature:

With silicon-supported ionic liquid catalyst; In ethanol; at 20 - 30 ℃; for 0.666667h;

Reference yield: 80.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 4-nitrobenzaldehdye (555-16-8) + urea (57-13-6) → 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (356566-57-9)

Guidance literature:

4-methyleneoxetan-2-one; With dmap; polystyrene Wang resin; In 1,4-dioxane; at 20 ℃; for 18h;

4-nitrobenzaldehdye; urea; With hydrogenchloride; In 1,4-dioxane; at 70 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

4-methyleneoxetan-2-one

4-nitrobenzaldehdye

urea

2-methyl-isourea

Downstream raw materials:

methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate