4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one

Base Information

Chemical Name:4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one
CAS No.:882041-53-4
Molecular Formula:C₁₈H₁₄BrNO₂
Molecular Weight:356.219
Hs Code.:
DSSTox Substance ID:DTXSID30468937
Mol file:882041-53-4.mol

Synonyms:882041-53-4;4-Bromo-1'-methyl-3-phenyl-5H-spiro[furan-2,3'-indolin]-2'-one;4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one;DTXSID30468937;4-Bromo-1'-methyl-3-phenyl-5H-spiro[furan-2,3'-indol]-2'(1'H)-one

Suppliers and Price of 4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-BROMO-1'-METHYL-3-PHENYL-SPIRO[FURAN-2(5H),3'-[3H]INDOL]-2'(1'H)-ONE 95.00%
5MG
$ 497.05

Total 2 raw suppliers

Chemical Property of 4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one

Chemical Property:

Boiling Point:542.217oC at 760 mmHg
Flash Point:281.723oC
PSA：29.54000
Density:1.57g/cm3
LogP:3.75970
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:355.02079
Heavy Atom Count:22
Complexity:511

Purity/Quality:

97% ^*data from raw suppliers

4-BROMO-1'-METHYL-3-PHENYL-SPIRO[FURAN-2(5H),3'-[3H]INDOL]-2'(1'H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C3(C1=O)C(=C(CO3)Br)C4=CC=CC=C4

Technology Process of 4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one

There total 3 articles about 4-Bromo-1'-methyl-3-phenyl-spiro[furan-2(5H),3'-[3H]indol]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 3-hydroxy-1-methyl-3-(1-phenyl-propa-1,2-dienyl)-1,3-dihydro-indol-2-one

: 882041-53-4
C₁₈H₁₄BrNO₂

Guidance literature:: With copper diacetate; potassium carbonate; lithium bromide; palladium diacetate; In acetonitrile; at 20 ℃; for 120h;
DOI:10.1021/jo0525027

Reference yield:

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 882041-53-4
C₁₈H₁₄BrNO₂

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / indium / tetrahydrofuran; H₂O / 2 h / 5 °C

2: 38 percent / lithium bromide; potassium carbonate; copper(II) acetate / palladium(II) acetate / acetonitrile / 120 h / 20 °C

With indium; copper diacetate; potassium carbonate; lithium bromide; palladium diacetate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo0525027

Reference yield:

: 1794-48-5
1-bromo-3-phenylprop-2-yne

: 882041-53-4
C₁₈H₁₄BrNO₂

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / indium / tetrahydrofuran; H₂O / 2 h / 5 °C

2: 38 percent / lithium bromide; potassium carbonate; copper(II) acetate / palladium(II) acetate / acetonitrile / 120 h / 20 °C

With indium; copper diacetate; potassium carbonate; lithium bromide; palladium diacetate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo0525027