[1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester
CAS No.:200490-71-7
Molecular Formula:C₂₉H₄₄FN₅O₄
Molecular Weight:545.698
Hs Code.:

Synonyms:[1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

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Chemical Property of [1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

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Technology Process of [1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

There total 8 articles about [1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59184-90-6
ethyl (piperidin-4-yl)acetate

: 200490-71-7
[1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / HATU, DIEA / CH₂Cl₂ / 18 h / Ambient temperature

2: TFA, anisole / 1 h

3: HOBt, WSCD*HCl / dimethylformamide

4: 1.) H₂S, Et₃N, 2.) MeI

With WSCD*HCl; hydrogen sulfide; benzotriazol-1-ol; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; methyl iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980126v

Reference yield:

: 115524-82-8
4-ethyl-3,3-dimethyl-2-azetidinone

: 200490-71-7
[1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / 6N aq. HCl / 24 h / Ambient temperature

2: 98 percent / 10percent aq. Na₂CO₃ / dioxane / Ambient temperature

3: 91 percent / HATU, DIEA / CH₂Cl₂ / 18 h / Ambient temperature

4: TFA, anisole / 1 h

5: HOBt, WSCD*HCl / dimethylformamide

6: 1.) H₂S, Et₃N, 2.) MeI

With hydrogenchloride; WSCD*HCl; hydrogen sulfide; sodium carbonate; benzotriazol-1-ol; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; methyl iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980126v

Reference yield:

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 200490-71-7
[1-(3-{2-Fluoro-4-[imino-(4-methyl-piperazin-1-yl)-methyl]-benzoylamino}-2,2-dimethyl-pentanoyl)-piperidin-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt, WSCD*HCl / dimethylformamide

2: 1.) H₂S, Et₃N, 2.) MeI

With WSCD*HCl; hydrogen sulfide; benzotriazol-1-ol; triethylamine; methyl iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm980126v