(S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

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Chemical Name:(S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide
CAS No.:1049811-12-2
Molecular Formula:C₂₁H₂₅ClIN₅O₃S
Molecular Weight:589.885
Hs Code.:

Synonyms:(S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

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Chemical Property of (S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

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Technology Process of (S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

There total 8 articles about (S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 471-47-6
oxamic acid

: 1-[3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-3-thiomorpholin-4-yl-propan-2-ol

: 1049811-12-2
(S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

Guidance literature:: oxamic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 1.25h;

1-[3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-3-thiomorpholin-4-yl-propan-2-ol; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

Reference yield:

: 42860-04-8
4-chloro-3-iodobenzoic acid

: 1049811-12-2
(S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 - 17 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

2.2: 16.5 h / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 21 h / 20 °C

4.1: ethanol / 20 h

5.1: trifluoroacetic acid / dichloromethane / 2 h

5.2: 0.25 h

6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.25 h

6.2: 0.25 h / 20 °C

With oxalyl dichloride; caesium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 42860-17-3
4-chloro-3-iodo-benzoyl chloride

: 1049811-12-2
(S)-2-[3-(4-chloro-3-iodo-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

1.2: 16.5 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 21 h / 20 °C

3.1: ethanol / 20 h

4.1: trifluoroacetic acid / dichloromethane / 2 h

4.2: 0.25 h

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.25 h

5.2: 0.25 h / 20 °C

With caesium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;