42860-04-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3-iodobenzoic acid is used as a building block for the preparation of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the synthesis of new and existing drugs, contributing to the development of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-3-iodobenzoic acid serves as a crucial intermediate for the synthesis of various agrochemicals. Its incorporation into these compounds helps in the development of effective pesticides and other agricultural products to protect crops and enhance yield.
Used in Dye Industry:
4-Chloro-3-iodobenzoic acid is utilized as a starting material in the production of dyes. Its chemical properties enable the creation of a diverse range of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Material Science:
4-Chloro-3-iodobenzoic acid has been studied for its potential use in the development of new materials. Its unique structure and properties make it a promising candidate for the synthesis of advanced materials with specific characteristics, such as high thermal stability or specific optical properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Chloro-3-iodobenzoic acid is employed as a versatile intermediate for the synthesis of various organic compounds with potential therapeutic applications. Its chemical versatility allows for the development of new drug candidates and the modification of existing ones to improve their efficacy and safety.

InChI:InChI=1/C7H4ClIO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)

Upstream product

• 276866-90-1 4-chloro-3-iodobenzaldehyde 
• 2840-28-0 3-amino-4-chloro-benzoic acid 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 42860-17-3 4-chloro-3-iodo-benzoyl chloride 
• 903522-13-4 6-chloro-4'-(2,6-difluorobenzamido)-[1,1'-biphenyl]-3-carboxylic acid 
• 877609-22-8 4-chloro-3-phenylethynyl-benzoic acid 
• 104317-95-5 (4-chloro-3-iodo-phenyl)-methanol 
• 710350-72-4 methyl 4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1232836-39-3 4-chloro-3-iodo-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 
• 181282-80-4 methyl-3-Cyano-4-chloro-benzoate 

Relevant academic research and scientific papers

Water bridges are essential to neonicotinoids: Insights from synthesis, bioassay and molecular modelling studies

Water-bridged H-bonds have been observed in many cases of ligand-receptor recognitions. To explore the roles of water bridges in the binding of neonicotinoids with receptors, twenty-four neonicotinoid compounds with nine fragments, including 1H-1,2,3-tria

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Oxidative iodination of deactivated arenes in concentrated sulfuric acid with I2/NaIO4 and KI/NaIO4 iodinating systems

Deactivated arenes were mono- or diiodinated with strong electrophilic I+ reagents, which were prepared from NaIO4 and either I2 or KI in concentrated H2SO4 (minimum 95% by weight). In general a small excess of the dark brown iodinating solution was used (1.1/1.5 equivalents, for nitrobenzene two equivalents was required). The iodinations were conducted at 25-30 °C with a reaction time of 1-2 hours using either a 'direct' or an 'inverse' method of aromatic iodination to give mono- or diiodinated pure products in 31-91% optimized yields. Georg Thieme Verlag Stuttgart.

A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent

Benzene, halobenzenes and some deactivated arenes readily reacted in anhydrous NaIO4/AcOH/Ac2O/concd. H2SO4 mixtures to afford, after quenching with excess aqueous Na2SO3 solution (a reducing agent), purified iodinated products in 27-88 percent yields. This novel method of aromatic iodination is simple, fairly effective and environmentally safe.

Synthesis and photochromic properties of substituted 3H-naphtho[2,1-b] pyrans

The synthesis and spectroscopic properties of novel 3H-naphtho[2,1-b]pyrans are described. Subtle variation of the colour of the photo-generated merocyanine dyes derived from these naphthopyrans can be accomplished by controlling the steric interactions between a terminal pyrrolidine donor group and a proximal substituent.

Easy, inexpensive and effective oxidative iodination of deactivated arenes in sulfuric acid

Two 'model' deactivated arenes, benzoic acid and nitrobenzene, were effectively monoiodinated within 1 h at 25-30 °C, with strongly electrophilic I+ reagents, prior prepared from diiodine and various oxidants (CrO3, KMnO4, active MnO2, HIO 3, NaIO3, or NaIO4) in 90% (v/v) concd sulfuric acid (ca. 75 mol% H2SO4). Next, an I2/ NaIO3/90% (v/v) concd H2SO4 exemplary system was used to effectively mono- or diiodinate a number of deactivated arenes. All former papers dealing with the direct iodination of deactivated arenes are briefly reviewed.

Substituted phenyl farnesyltransferase inhibitors

Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.