N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Base Information

Chemical Name:N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide
CAS No.:894853-77-1
Molecular Formula:C₂₈H₃₈ClF₂NO₅S₂Si
Molecular Weight:634.281
Hs Code.:

<i>N</i>-allyl-<i>N</i>-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Synonyms:N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Suppliers and Price of N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

There total 8 articles about N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 894853-76-0
N-[(1R,2S,4S)-4-(4-Chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

: 106-95-6
allyl bromide

: 894853-77-1
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1016/j.bmcl.2005.12.083

Reference yield:

: 471903-20-5
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone

: 894853-77-1
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: nBuLi; LiCl; [S-(R*,R*)]-(-)-bis-α-methylbenzylamine / tetrahydrofuran / -100 °C

1.2: 75 percent / SnCl₄ / CH₂Cl₂ / -40 °C

2.1: 80 percent / NaBH₄ / propan-2-ol / -20 °C

3.1: 97 percent / Et₃N / CH₂Cl₂

4.1: 75 percent / NaN₃ / dimethylformamide / 90 °C

5.1: 95 percent / Ph₃P; water / tetrahydrofuran

6.1: 95 percent / Et₃N / CH₂Cl₂

7.1: 70 percent / NaH / dimethylformamide / 70 °C

With sodium tetrahydroborate; n-butyllithium; sodium azide; [S-(R*,R*)]-(-)-bis-α-methylbenzylamine; water; sodium hydride; triethylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.12.083

Reference yield:

: 894853-74-8
(2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone

: 894853-77-1
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / NaBH₄ / propan-2-ol / -20 °C

2: 97 percent / Et₃N / CH₂Cl₂

3: 75 percent / NaN₃ / dimethylformamide / 90 °C

4: 95 percent / Ph₃P; water / tetrahydrofuran

5: 95 percent / Et₃N / CH₂Cl₂

6: 70 percent / NaH / dimethylformamide / 70 °C

With sodium tetrahydroborate; sodium azide; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.12.083