3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

Base Information

Chemical Name:3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine
CAS No.:221148-45-4
Molecular Formula:C₂₀H₁₇N₃O₃S
Molecular Weight:379.439
Hs Code.:

Synonyms:3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

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Chemical Property of 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

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Technology Process of 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

There total 5 articles about 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 3-bromo-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

: 221148-45-4
3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; Heating;
DOI:10.1016/j.bmcl.2004.07.089

Reference yield:

: 497-19-8
sodium carbonate

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 781674-50-8
2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester

: 221148-45-4
3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

Guidance literature:: With N-Bromosuccinimide; aq. sodium hydroxide; sodium hydrogencarbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 7515-17-5
methyl 3-(4-methoxyphenyl)propynoate

: 221148-45-4
3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: DBU / acetonitrile / 25 °C

2: aq. NaOH / ethanol / Heating

3: N-bromosuccinimide; sodium bicarbonate / dimethylformamide / 25 °C

4: Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / Heating

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.07.089