3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

Base Information

Chemical Name:3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride
CAS No.:925917-91-5
Molecular Formula:C₂₀H₁₉ClN₄O₃*ClH
Molecular Weight:435.31
Hs Code.:

Synonyms:3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

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Chemical Property of 3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

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Technology Process of 3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

There total 10 articles about 3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925979-45-9
3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide

: 925917-91-5
3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether;

Reference yield:

: 871819-39-5
2-methoxycarbonylmethyl-1-methyl-1H-pyrrole-3-carboxylic acid methyl ester

: 925917-91-5
3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

2.1: ammonium acetate / methanol / 2 h / Heating / reflux

3.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave

4.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C

5.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

5.2: pH 1

6.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

7.1: lithium hexamethyldisilazane; CyJohnPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 17 h / 65 °C

8.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

9.1: hydrogenchloride / methanol; diethyl ether

With N-ethylmorpholine;; hydrogenchloride; sodium hydroxide; ammonium acetate; water; sodium hydride; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; sodium t-butanolate; CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 871819-42-0
1-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester

: 925917-91-5
3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C

2.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

2.2: pH 1

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4.1: lithium hexamethyldisilazane; CyJohnPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 17 h / 65 °C

5.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

6.1: hydrogenchloride / methanol; diethyl ether

With N-ethylmorpholine;; hydrogenchloride; sodium hydroxide; water; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;