4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester
• CAS No.: 74128-33-9
• Molecular Formula: C₁₂H₁₅ClO₆S
• Molecular Weight: 322.767

Synonyms:4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester

Chemical Property of 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester

There total 2 articles about 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

Methyl 2,3-anhydro-4-O-(p-chlorobenzenesulfonyl)-β-L-lyxopyranoside (74128-31-7) → 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester (74128-33-9) + 4-Chloro-benzenesulfonic acid (3R,5R,6S)-5-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester (74128-35-1)

Guidance literature:

With sodium tetrahydroborate; diborane; In tetrahydrofuran; at 70 ℃;

DOI:10.1021/jo01307a021

Reference yield:

4-chlorobenzenesulfonyl chloride (98-60-2) → 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester (74128-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃; pyridine / 24 h

2: 65 percent / diborane, NaBH₄ / tetrahydrofuran / 70 °C

With sodium tetrahydroborate; diborane; In tetrahydrofuran; pyridine; chloroform;

DOI:10.1021/jo01307a021

Reference yield:

acetic anhydride (108-24-7) + 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester (74128-33-9) → Methyl 3-O-acetyl-4-O-(p-chlorobenzenesulfonyl)-2-deoxy-β-L-threo-pentopyranoside (74128-37-3)

Guidance literature:

In pyridine;

DOI:10.1021/jo01307a021

upstream raw materials:

Methyl 2,3-anhydro-4-O-(p-chlorobenzenesulfonyl)-β-L-lyxopyranoside

4-chlorobenzenesulfonyl chloride

Downstream raw materials:

Methyl 3-O-acetyl-4-O-(p-chlorobenzenesulfonyl)-2-deoxy-β-L-threo-pentopyranoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 74128-33-9 4-Chloro-benzenesulfonic acid (3S,4S,6S)-4-hydroxy-6-methoxy-tetrahydro-pyran-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send