ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate

Base Information

• Chemical Name: ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate
• CAS No.: 1067631-47-3
• Molecular Formula: C₂₁H₃₀O₃Si
• Molecular Weight: 358.553
• Mol file: 1067631-47-3.mol

Synonyms:ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate

Chemical Property of ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate

There total 3 articles about ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

triethylsilane (617-86-7) + Phenylpropargyl aldehyde (2579-22-8) + ethyl acetoacetate (141-97-9) → ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate (1067631-47-3)

Guidance literature:

With zinc(II) chloride; In neat (no solvent); at 60 ℃; for 70h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201501155

Reference yield: 57.0%

triethylsilane (617-86-7) + C15H14O3 (947587-36-2) → ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate (1067631-47-3)

Guidance literature:

With tetrakis(acetonitrile)copper(I) tetrafluoroborate; In dichloromethane; at 20 ℃;

DOI:10.1021/ja8058342

Reference yield: 53.0%

triethylsilane (617-86-7) + 2-Acetyl-5-phenyl-pent-2-en-4-insaeure-ethylester (14499-33-3) → ethyl 2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-carboxylate (1067631-47-3)

Guidance literature:

In toluene; at 140 ℃; for 12h; Microwave irradiation;

DOI:10.1002/adsc.201601037

upstream raw materials:

triethylsilane

C₁₅H₁₄O₃

Phenylpropargyl aldehyde

ethyl acetoacetate