1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

Base Information

Chemical Name:1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine
CAS No.:1354030-76-4
Molecular Formula:C₂₁H₂₅Cl₂N₃O₃
Molecular Weight:438.354
Hs Code.:

Synonyms:1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

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Chemical Property of 1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

Chemical Property:

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Technology Process of 1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

There total 3 articles about 1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 119532-26-2,864512-47-0
1-(2,3-dichlorophenyl)-piperazine hydrochloride

: 75716-49-3
1-Bromo-4-(4-methyl-3-nitrophenoxy)butane

: 1354030-76-4
1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;

Reference yield:

: 56961-77-4
1-bromo-2,3-dichlorobenzene

: 1354030-76-4
1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 60 - 70 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 1.5 h / 20 °C

3.1: potassium carbonate / acetonitrile / Reflux

With hydrogenchloride; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethyl acetate; toluene; acetonitrile;

Reference yield:

: tert-butyl 4-(2,3-dichlorophenyl)piperazine-1-carboxylate

: 1354030-76-4
1-(2,3-dichlorophenyl)-4-(4-(4-methyl-3-nitrophenoxy)butyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 1.5 h / 20 °C

2: potassium carbonate / acetonitrile / Reflux

With hydrogenchloride; potassium carbonate; In ethyl acetate; acetonitrile;