2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Chemical Name:2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide
CAS No.:1394939-87-7
Molecular Formula:C₂₅H₂₁F₂N₃O₃S₂
Molecular Weight:513.589
Hs Code.:

Synonyms:2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Chemical Property of 2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Technology Process of 2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

There total 8 articles about 2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1394939-91-3
3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1394939-87-7
2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: 3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline; 2,5-difluorobenzenesulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 110238-91-0
tetrahydropyran-4-carboxylic acid methyl ester

: 1394939-87-7
2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia / water / 18 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux

3.1: ethanol / 2 h / Reflux

4.1: sodium acetate; acetic acid / 0.5 h

5.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux

6.1: zinc; acetic acid / ethanol / 3 h / Reflux

6.2: 1 h

6.3: pH 14

7.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With Lawessons reagent; pyridine; ammonia; sodium acetate; caesium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 344329-76-6
tetrahydro-pyran-4-carboxylic acid amide

: 1394939-87-7
2,5-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux

2.1: ethanol / 2 h / Reflux

3.1: sodium acetate; acetic acid / 0.5 h

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux

5.1: zinc; acetic acid / ethanol / 3 h / Reflux

5.2: 1 h

5.3: pH 14

6.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With Lawessons reagent; pyridine; sodium acetate; caesium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;