3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

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Chemical Name:3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline
CAS No.:1394939-91-3
Molecular Formula:C₁₉H₁₉N₃OS
Molecular Weight:337.445
Hs Code.:

Synonyms:3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

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Chemical Property of 3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

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Technology Process of 3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

There total 6 articles about 3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1394939-90-2
4-[4-(3-nitrophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridine

: 1394939-91-3
3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

Guidance literature:: 4-[4-(3-nitrophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridine; With acetic acid; zinc; In ethanol; for 3h; Reflux;

With hydrogenchloride; In water; for 1h;

With sodium hydroxide; pH=14;

Reference yield:

: 110238-91-0
tetrahydropyran-4-carboxylic acid methyl ester

: 1394939-91-3
3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia / water / 18 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux

3.1: ethanol / 2 h / Reflux

4.1: sodium acetate; acetic acid / 0.5 h

5.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux

6.1: zinc; acetic acid / ethanol / 3 h / Reflux

6.2: 1 h

6.3: pH 14

With Lawessons reagent; ammonia; sodium acetate; caesium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 344329-76-6
tetrahydro-pyran-4-carboxylic acid amide

: 1394939-91-3
3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux

2.1: ethanol / 2 h / Reflux

3.1: sodium acetate; acetic acid / 0.5 h

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux

5.1: zinc; acetic acid / ethanol / 3 h / Reflux

5.2: 1 h

5.3: pH 14

With Lawessons reagent; sodium acetate; caesium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; water;