{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

Base Information

Chemical Name:{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester
CAS No.:301838-53-9
Molecular Formula:C₃₁H₄₂N₂O₆Si
Molecular Weight:566.77
Hs Code.:

{5-benzyloxy-2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

Synonyms:{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

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Chemical Property of {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

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Technology Process of {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

There total 1 articles about {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 260417-69-4
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 301838-53-9
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield: 88.0%

: 301838-53-9
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 260418-18-6
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-2-(hydroxymethyl)-4-methylidenepyrrolidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield:

: 301838-53-9
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 260546-06-3
(11aS)-8-benzyloxy-7-methoxy-2-methylidene-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0 °C

2: 66 percent / (COCl)2; DMSO; TEA / CH₂Cl₂ / -45 °C

3: 100 percent / Pd(PPh₃)4; PPh₃; pyrrolidine / CH₂Cl₂

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; TEA; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: desilylation / 2: oxidative cyclisation / 3: Elimination;
DOI:10.1016/S0960-894X(00)00351-6