trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester
CAS No.:936902-00-0
Molecular Formula:C₁₃H₁₉N₅O₄
Molecular Weight:309.325
Hs Code.:

Synonyms:trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

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Chemical Property of trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

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Technology Process of trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

There total 2 articles about trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936901-99-4
Methyl trans-4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}cyclohexanecarboxylate

: 93206-03-2
3-amino-6-((dibenzylamino)methyl)-1,2,4-triazine-5-(4H)-one

: 936902-00-0
trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

Guidance literature:: 3-amino-6-((dibenzylamino)methyl)-1,2,4-triazine-5-(4H)-one; With hydrogen; acetic acid; palladium 10% on activated carbon; In water; at 55 ℃; Industry scale; Inert atmosphere;

With triethylamine; In acetonitrile; Industry scale;

Methyl trans-4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}cyclohexanecarboxylate; In acetonitrile; at 50 ℃; Industry scale;

Reference yield:

: 103-49-1
dibenzylamine

: 936902-00-0
trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl acetate / 60 - 80 °C / Industry scale

1.2: 24 h / Reflux; Industry scale

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 55 °C / Industry scale; Inert atmosphere

2.2: Industry scale

2.3: 50 °C / Industry scale

With hydrogen; acetic acid; palladium 10% on activated carbon; In water; ethyl acetate;

Reference yield: 95.0%

: 936902-00-0
trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester

: 936902-01-1
trans-4-(2-amino-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid methyl ester

Guidance literature:: trans-4-[(3-amino-5-oxo-4,5-dihydro[1,2,4]triazin-6-ylmethyl)carbamoyl]cyclohexanecarboxylic acid methyl ester; With trichlorophosphate; In acetonitrile; Reflux; Industry scale;

With potassium carbonate; In water; acetonitrile; at 0 - 30 ℃; for 1h; pH=8; Industry scale;