Technology Process of benzyl 6-hydroxy-4-azaspiro[2,5]octane-4-carboxylate
There total 6 articles about benzyl 6-hydroxy-4-azaspiro[2,5]octane-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
tetrahydrofuran;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: titanium tetra-n-propoxide / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
2: hydrogen; palladium on activated charcoal; hydrogenchloride / methanol; water / 48 h / 60 °C
3: sodium hydrogencarbonate / tetrahydrofuran / 48 h / 20 °C
With
hydrogenchloride; titanium tetra-n-propoxide; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen; palladium on activated charcoal / methanol / 24 h / 60 °C
2: sodium hydride / mineral oil; dimethyl sulfoxide / 20 °C
3: titanium tetra-n-propoxide / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
4: hydrogen; palladium on activated charcoal; hydrogenchloride / methanol; water / 48 h / 60 °C
5: sodium hydrogencarbonate / tetrahydrofuran / 48 h / 20 °C
With
hydrogenchloride; titanium tetra-n-propoxide; palladium on activated charcoal; hydrogen; sodium hydride; sodium hydrogencarbonate;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; mineral oil;