87179-79-1

Upstream product

• 100-39-0 benzyl bromide 
• 24211-54-9 (S)-5-hydroxypiperidin-2-one 
• 625437-73-2 (S)-N-benzyl-5-oxotetrahydrofuran-2-carboxamide 
• 87179-80-4 (S)-1-benzyl-5-hydroxypiperidin-2-one 
• 19365-07-2 (RS)-5-hydroxypiperidin-2-one 
• 100-44-7 benzyl chloride 
• 179532-81-1 5-(azidomethyl)dihydrofuran-2(3H)-one 
• 10374-51-3 5-hydroxymethyl-4,5-dihydrofuranone 
• 57859-04-8 (5-oxotetrahydrofuran-2-yl)methyl formate 
• 591-80-0 pent-4-enoic acid 
• 1179999-39-3 methyl 4-hydroxy-5-nitropentanoate 
• 5154-01-8 2,5-dihydroxypyridine 
• 52065-78-8 piperidine-2,5-dione 

Downstream Products

• 124032-31-1 benzyl 6-hydroxy-4-azaspiro[2,5]octane-4-carboxylate 
• 87179-80-4 1-benzyl-5-hydroxypiperidin-2-one 
• 134746-55-7 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon 
• 134746-54-6 (S)-1-Benzyl-5-(tert-butyl-diphenyl-silanyloxy)-piperidin-2-one 
• 134746-56-8 1-Benzyl-5S-t-butyldiphenylsiloxy-3,4-dehydro-2-piperidon 
• 87179-80-4 (S)-1-benzyl-5-hydroxypiperidin-2-one 

Relevant academic research and scientific papers

CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR

Disclosed is a new crystal form of a 5-aminopyrazole carboxamide compound as shown in Formula (I). Also disclosed are a preparation method for said crystal form of said compound, a pharmaceutical composition of said crystal form of said compound, and uses thereof.

N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF

The present application discloses novel 5-aminopyrazole carboxamide compounds as shown in formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof. In addition, the present application further discloses a method for the preparation of the compounds, a pharmaceutical composition comprising a compound of the invention and the use of the compounds.

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

The combination of amide activation by Tf2O with B(C6F5)3-catalyzed hydrosilylation with TMDS constitutes a method for the one-pot reduction of secondary amides to amines under mild conditions. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for many sensitive functional groups. Reductions of a multifunctionalized α,β-unsaturated amide obtained from another synthetic methodology, and a C-H functionalization product produced the corresponding amines in good to excellent yield. Chemoselective reduction of enantiomeric pure (ee >99%) tetrahydro-5-oxo-2-furaneamides yielded 5-(aminomethyl)dihydrofuran-2(3H)-ones in a racemization-free manner. The latter were converted in one pot to N-protected 5-hydroxypiperidin-2-ones, which are building blocks for the synthesis of many natural products. Further elaboration of an intermediate led to a concise four-step synthesis of -epi-pseudoconhydrine.

Nonracemic bicyclic lactam lactones via regio- and cis-diastereocontrolled C-H insertion. Asymmetric synthesis of (8S,8aS)-octahydroindolizidin-8-ol and (1S,8aS)-octahydroindolizidin-1-ol

(Chemical Equation Presented) The Rh2(MPPIM)4- catalyzed intramolecular C-H insertion reaction of (S)- and (R)-1-benzyl-5-(R- diazoacetoxy)piperidin-2-one and (S)-1-benzyl-4-(α-diazoacetoxy) pyrrolidin-2-one proceeds with high regios