2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester
• CAS No.: 691888-40-1
• Molecular Formula: C₂₈H₃₁F₃O₄
• Molecular Weight: 488.547

Synonyms:2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester

Chemical Property of 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester

There total 5 articles about 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl(diethylphosphono)(fluoro)acetate (2356-16-3) + 2-Acetyl-7-[3,5-diisopropyl-2-(2,2-difluoroethoxy)phenyl]-benzo[b]furan (460087-06-3) → 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester (691888-40-1)

Guidance literature:

With NaH; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-Fluoro-2-phosphonoacetic acid triethyl ester (110624-98-1) + 2-Acetyl-7-[3,5-diisopropyl-2-(2,2-difluoroethoxy)phenyl]-benzo[b]furan (460087-06-3) → 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester (691888-40-1)

Guidance literature:

2-Fluoro-2-phosphonoacetic acid triethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

2-Acetyl-7-[3,5-diisopropyl-2-(2,2-difluoroethoxy)phenyl]-benzo[b]furan; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2003.12.089

Reference yield:

trifluoro-methanesulfonic acid 2-acetyl-benzofuran-7-yl ester (460086-97-9) → 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester (691888-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

2.1: Cs₂CO₃ / dimethylformamide / 20 °C

3.1: NaH / dimethylformamide / 0 °C

3.2: dimethylformamide / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; caesium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2003.12.089

upstream raw materials:

2-Fluoro-2-phosphonoacetic acid triethyl ester

2-Acetyl-7-[3,5-diisopropyl-2-(2,2-difluoroethoxy)phenyl]-benzo[b]furan

2-acetyl-7-hydroxybenzofuran

trifluoro-methanesulfonic acid 2-acetyl-benzofuran-7-yl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 691888-40-1 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send