3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

Base Information

Chemical Name:3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside
CAS No.:1521271-27-1
Molecular Formula:C₄₂H₃₁F₂NO₁₀
Molecular Weight:747.706
Hs Code.:

Synonyms:3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

Suppliers and Price of 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

There total 3 articles about 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 188435-38-3
bromide 2,3,4,6-tetra-O-Bz-α-D-galactopyranosyl bromide

: 197067-27-9
3,3-difluoro-1,3-dihydro-2H-indol-2-one

: 1521271-27-1
3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

Guidance literature:: bromide 2,3,4,6-tetra-O-Bz-α-D-galactopyranosyl bromide; In dichloromethane; at 20 ℃; for 1h; Molecular sieve; Inert atmosphere;

3,3-difluoro-1,3-dihydro-2H-indol-2-one; With N-ethyl-N,N-diisopropylamine; silver(l) oxide; In dichloromethane; at 0 - 20 ℃; for 6h; Molecular sieve; Inert atmosphere;
DOI:10.1039/c6ob02230h

Reference yield:

: 2592-58-7,3006-48-2,3006-49-3,13526-09-5,14679-57-3,22415-91-4,29884-70-6,41545-55-5,41545-56-6,41569-33-9,96996-90-6,121570-85-2,121570-86-3
1,2,3,4,6-Penta-O-benzoyl-α-D-galactopyranose

: 1521271-27-1
3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / dichloromethane / 20 °C / Inert atmosphere

2: silver(l) oxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In dichloromethane;
DOI:10.1021/ja411746a

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1521271-27-1
3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / Inert atmosphere

2: silver(l) oxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

With diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In dichloromethane;
DOI:10.1021/ja411746a