197067-27-9

Basic information

• Product Name: 3,3-difluoro-1,3-dihydro-2H-Indol-2-one
• Synonyms: 3,3-difluoro-1,3-dihydro-2H-Indol-2-one;3,3-Difluoroindolin-2-one
• CAS NO: 197067-27-9
• Molecular Formula: C₈H₅F₂NO
• Molecular Weight: 169.1282064
• Mol File: 197067-27-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 251.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.24±0.40(Predicted)
• CAS DataBase Reference: 3,3-difluoro-1,3-dihydro-2H-Indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-difluoro-1,3-dihydro-2H-Indol-2-one(197067-27-9)
• EPA Substance Registry System: 3,3-difluoro-1,3-dihydro-2H-Indol-2-one(197067-27-9)

Safety Data

• Hazardous Substances Data: 197067-27-9(Hazardous Substances Data)

Usage

General Description

3,3-difluoro-1,3-dihydro-2H-Indol-2-one is a chemical compound with the molecular formula C8H6F2NO. It is a white solid that is commonly used as a building block in organic synthesis. 3,3-difluoro-1,3-dihydro-2H-Indol-2-one is a fluoro-substituted 1,3-dihydro-2H-indol-2-one, which has potential antipsychotic and antitumor properties. It is used in pharmaceutical research as a precursor in the synthesis of various pharmaceutical compounds. Additionally, it has also been studied for its potential use in the development of new medicinal drugs due to its unique chemical structure and properties.

Upstream product

• 2365-44-8 3-hydrazonoindolin-2-one 
• 667-27-6 Ethyl bromodifluoroacetate 
• 62-53-3 aniline 
• 221665-91-4 1-benzyl-3,3-difluoroindolin-2-one 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1521271-27-1 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside 
• 1521271-16-8 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzyl-β-D-glucopyranoside 
• 1521271-18-0 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzyl-α-D-mannopyranoside 
• 1521271-14-6 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzyl-α-D-glucopyranoside 
• 1521271-28-2 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranoside 
• 1521271-26-0 3,3-difluoro-3H-indol-2-yl 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranoside 
• 1521271-22-6 3,3-difluoro-3H-indol-2-yl 3,4,6-tri-O-acetyl-2-O-benzyl-α-D-glucopyranoside 
• 1521271-20-4 3,3-difluoro-3H-indol-2-yl 3,4,6-tri-O-acetyl-2-O-benzyl-β-D-glucopyranoside 
• 1352949-53-1 tert-butyl 3-((8-(3-(3,3-difluoro-2-oxoindolin-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate 

Relevant articles and documents

Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.

INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE

Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

PHARMACEUTICAL COMPOUNDS

Benzimidazole derivatives of formula (I): (Formula (I)) wherein: R1is -(CH2)m-R7, (Formula (II)) or (Formula (III)); R2 is H, halo, -(CH2)m-NH2, -(CH2)n-C(=NH)-NH2 or -(CH2)n-NH-(CH2)m-NHR9; R3 is H, F or Cl; each of R4, R5 and R6 is independently H or F; R7 is C1-C6 alkyl, CF3, -SO2R11, -NH-(CH2)2-(NH)r-R8, -NH-CH(R8R9) or a group of the following formula (A): (Formula (A)): W is -(CH2)m-, -CH2-O-CH2-, -CH2-S-CH2-, -(CH2)r-S(O)2-CH2-or -(CH2)r-NR8-CH2-; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R8 is H, -SO2R11,-SO2CF3, -COR11, -C(O)OR11, -CON(R9)2 or -(CH2)nSO2R11; R9 is H or C1-C6 alkyl, each R9 being the same or different when two are present; R10 is -SO2R11, -SO2CF3, -COR11, -CON(R9)2 or -(CH2)nSO2R11; and R11 is C1-C6 alkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.