2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide
CAS No.:1333337-13-5
Molecular Formula:C₃₉H₃₀FN₃O₅S
Molecular Weight:671.749
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

There total 15 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1333337-33-9
2-(4-fluorophenyl)-5-(4-hydroxy-3-(1H-indol-2-yl)phenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 100-52-7
benzaldehyde

: 1333337-13-5
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1216260-79-5
2-(5-bromo-2-methoxyphenyl)-1H-indole

: 1333337-13-5
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / toluene / 3 h / 90 °C / Inert atmosphere

2: potassium phosphate tribasic trihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 5 h / 0 - 20 °C

4: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 130 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate; potassium acetate; boron tribromide; toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1427034-68-1
2-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-indole

: 1333337-13-5
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6-phenyl-6,11-dihydrochromeno[4,3-b]indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate tribasic trihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 5 h / 0 - 20 °C

3: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 130 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate; boron tribromide; toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide;