(2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Base Information

• Chemical Name: (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide
• CAS No.: 605665-80-3
• Molecular Formula: C₁₅H₁₉FN₂O₅S
• Molecular Weight: 358.391
• Mol file: 605665-80-3.mol

Synonyms:(2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Chemical Property of (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

There total 4 articles about (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

L-homoserine lactone hydrochloride (2185-03-7) + N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester (190275-58-2) → (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (605665-80-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/S0968-0896(02)00612-0

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (605665-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / 1M NaOH / tetrahydrofuran; H₂O / 18 h / 20 °C

2: 94 percent / RDC*HCl / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

3: 43 percent / Et₃N / dimethylformamide / 18 h / 20 °C

With sodium hydroxide; RDC*HCl; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(02)00612-0

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) → (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (605665-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / 1M NaOH / tetrahydrofuran; H₂O / 18 h / 20 °C

2: 94 percent / RDC*HCl / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

3: 43 percent / Et₃N / dimethylformamide / 18 h / 20 °C

With sodium hydroxide; RDC*HCl; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(02)00612-0

upstream raw materials:

L-homoserine lactone hydrochloride

N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester

L-valine

4-Fluorobenzenesulfonyl chloride